Formation in Adaptively Tolerant T Cells Impairment of Immunological Synapse
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Coordination of T cell activation and migration through formation of the immunological synapse.
T cell activation is based on interactions of T cell antigen receptors with MHC-peptide complexes in a specialized cell-cell junction between the T cell and antigen-presenting cell-the immunological synapse. The immunological synapse coordinates naïve T cell activation and migration by stopping T cell migration with antigen-presenting cells bearing appropriate major histocompatibility complex (...
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A stable supramolecular cluster in T cells at the contact site of APCs, the immunological synapse (IS), is essential for full T cell activation. Failure of IS maturation, as determined by defective relocalization of the TCR/CD3 complex at the T cell/APC contact site, is linked with T cell hyporesponsiveness. The effects of clinically used immunosuppressants on these critical events, however, ar...
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The immunological synapse is a highly structured and molecularly dynamic interface between communicating immune cells. Although the immunological synapse promotes T cell activation by dendritic cells, the specific organization of the immunological synapse on the dendritic cell side in response to T cell engagement is largely unknown. In this study, confocal and electron microscopy techniques we...
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The discovery of the immunological synapse is one of the more striking developments in T cell biology in recent years. The immunological synapse forms at the interface between T cells and antigen-presenting cells (APCs) or target cells. It is characterised by the large-scale segregation of cell surface molecules into concentric zones, forming a bull's eye pattern several microns in diameter (re...
متن کاملT cell receptor signaling precedes immunological synapse formation.
The area of contact between a T cell and an antigen-presenting cell (APC) is known as the immunological synapse. Although its exact function is unknown, one model suggests that it allows for T cell receptor (TCR) clustering and for sustained signaling in T cells for many hours. Here we demonstrate that TCR-mediated tyrosine kinase signaling in naïve T cells occurred primarily at the periphery o...
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تاریخ انتشار 2011